Population Pharmacokinetics of Emtricitabine in HIV-1-Infected Adult Patients
نویسندگان
چکیده
منابع مشابه
Population pharmacokinetics of emtricitabine in HIV-1-infected adult patients.
The aims of this study were to describe emtricitabine concentration-time courses in a large population of HIV-1-infected adults, to evaluate the influence of renal function on emtricitabine disposition, and to assess current dosing adjustment recommendations. Emtricitabine blood plasma concentrations were determined from samples collected from 161 adult patients during therapeutic drug monitori...
متن کاملPopulation Pharmacokinetics of Emtricitabine in HIV-1 infected Pregnant Women and their neonates (ANRS 12109)
1 Objectives: To evaluate emtricitabine (FTC) pharmacokinetics (PK) in pregnant women and 2 their neonates and to determine the optimal prophylactic dose for neonates after birth to 3 prevent mother-to-child transmission of HIV (PMTCT). 4 Methods: 38 HIV-infected pregnant women were administered Tenofovir Disoproxyl 5 Fumarate (TDF, 300mg)emtricitabine (FTC, 200mg) tablets: 2 at the initiation ...
متن کاملPopulation pharmacokinetics of nevirapine in Thai HIV-infected patients.
BACKGROUND Nevirapine-based antiretroviral therapy is widely used as a first-line treatment for HIV-infected patients in resource-limited settings. Nevirapine plasma concentration has been shown to be associated with virological response and treatment failure. Therefore, identifying sources of the variability of nevirapine pharmacokinetics is important for dose optimization. The purpose of the ...
متن کاملPopulation pharmacokinetics of dolutegravir in HIV-infected treatment-naive patients
AIM Dolutegravir is the newest integrase inhibitor approved for HIV treatment and has demonstrated potent antiviral activity in patient populations with a broad range of treatment experience. This analysis aimed to characterize the population pharmacokinetics of dolutegravir in treatment-naive patients and to evaluate the influence of patient covariates. METHODS A population pharmacokinetic m...
متن کاملThe pharmacokinetics, safety and efficacy of tenofovir and emtricitabine in HIV-1-infected pregnant women.
OBJECTIVE To describe the pharmacokinetics of tenofovir and emtricitabine in the third trimester of pregnant HIV-infected women and at postpartum. DESIGN A nonrandomized, open-label, multicentre phase IV study in HIV-infected pregnant women recruited from HIV treatment centres in Europe. METHODS HIV-infected pregnant women treated with the nucleotide/nucleoside analogue reverse transcriptas...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02058-13